CONTENTS
Autumn 2025
Imaging and Sensing
10 Analytics for a new therapeutic era: meeting the demands of modern biologics
Single-particle technologies can deliver faster, clearer insights and support the next generation of advanced therapies.
14 Transforming R&D workflows with automated super-resolution microscopy
What is super-resolution microscopy and how is it accelerating progress across the imaging sector?
18 LVEM: a new tool for AAV gene therapy and pharmaceutical development
How is low voltage electron microscopy revolutionising the electron microscopy landscape – making the practice more accessible in pharma labs?
21 Lessons learned from sequencing: a smart beginning for meaningful results
Massive sequencing, or next-generation sequencing, has opened the door to the fascinating world of genetics, and the secret on how to use this powerful tool most effectively hinges on the starting point: the sample.
Manufacturing
SPOT LIGHT
24 Tablet density uniformity
Bill Supplee at Natoli Engineering discusses the best ways to ensure tablet density uniformity in pharma products.
26 Why advanced contamination detection systems are essential for pharmaceutical manufacturing
What are eight compelling reasons why manufacturers should prioritise the use of advanced contamination detection systems in their operations?
29 Clone selection as a strategic lever: balancing speed, quality and long-term viability in CLD
How can thoughtful clone selection – integrated with developability and manufacturability assessments – accelerate speed to clinic while safeguarding long-term success?
SPOT LIGHT
32 Delivering precision at every stage: integrated API and sterile drug product services
How CARBOGEN AMCIS supports complex molecules and challenging formulations from early development to commercialisation.
34 Advancing complex SM process development using biocatalysis
Biocatalysis is enhancing complex molecule process development. By merging the power of enzymes with chemical synthesis, scientists and manufacturers are addressing long-standing challenges in stereoselectivity, route complexity and sustainability.
Discovery and Development
38 The increasing pivotal role of predictivein vitrotechnologies in drug discovery
How will innovative human-centred in vitro testing strategies contribute to accelerating the delivery of safer and more effective therapies to patients without, or with minimal, use of animal models?
41 How proteomics and digital transformation can redefine therapeutic discovery
How are recent advances in proteomics, such as artificial intelligence and machine learning, transforming drug discovery and development?
45 Viral clearance in advanced therapies
hould viral clearance studies be required for genetically engineered viral vectors and viral vector-derived products?
48 ssDNA: a novel approach to overcome efficacy and immunogenicity challenges in genetic medicines
What is single-stranded DNA and why is it a viable viral vector alternative?
Lab Design
63 Smarter labs, better discovery: how automation is evolving pharma R&D
How is the industry translating the potential of automated technologies into practical, flexible and scalable workflows that address the real-world challenges of modern laboratories, ensuring that innovation delivers measurable scientific and operational gains?
Digital
52 Designing tomorrow’s biologics: how AI is enablingde novoprotein discovery
Artificial intelligence-powered de novo protein design is opening new pathways in biologics discovery, allowing researchers to create synthetic proteins beyond nature’s existing repertoire.
56 Proving value in the age of drug discovery transformation
How is artificial intelligence changing the way drug discovery and development is enacted across the sector, yielding not only impressive potential, but also clinically validated pharma products?
60 AI and SaaS: reshaping business outcomes in pharma manufacturing
How is artificial intelligence, when delivered through software as a service platforms, unlocking real business outcomes for pharmaceutical manufacturers, from faster batch release and smarter investigations to smoother tech transfers and enterprise-wide compliance?
Regulars
6 Eds Desk
As the days get cooler, IPT takes the time to reflect on innovations in the pharma sector.
8 Product News
IPT highlights some of the most recent exciting advancements in pharmaceutical manufacturing.
66 Events
A collation of the top Pharma events for Autumn 2025!
Index of Advertisers
IFC. CARBOGEN AMCIS
7. EHP Awards
55. PMOS
OBC. Natoli
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Innovations in Pharmaceutical Technology (ISSN: 1471-7204, USPS No: 025082) is published four times a year – March, June, September, and December – by Samedan Ltd.
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