CONTENTS

Spring 2023

Analytics

6. Approaches to Advance Viral Vector Development and Characterisation for Gene Therapy Applications – AJourney Through Vector Optimisation

How is rAAV vectorology being optimised and why is its development important?

10. The Challenges and Technological Opportunities in Oligonucleotide Therapeutics

How are nucleic acid sequences being analysed by mass spectrometry and how can the data be automatically processed?

Discovery & Development

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18. AI in the Drug Discovery Industry

IPT talks to Tamsin Mansley of Optibrium about AI’s past and future involvement in drug discovery

20. Coding of Cell Identity

How are novel technologies helping researchers improve on non-human cells in drug discovery?

Feature

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23. The Big Debate: The Future of Life Sciences’ Regulation and Processes Will Be Data-Driven – But Who Will Steer That Future?

Whose responsibility should it be to look after the quality and consistency of data, and how will they achieve this?

Digital

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26. Accelerating Life Sciences Research and Delivery with Knowledge Graphs

Two studies demonstrate how knowledge graphs are improving data handling in drug discovery

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30. Technological and Scientific Advances Bring New Hope for Therapeutic Cancer Vaccines

Cancer vaccines are becoming a reality through advances in immunotherapy and other areas

Manufacturing

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33. Next-Generation Enteric Capsule Innovation: How Next-Generation Capsule Technology is Helping API Reach Deeper Into the Small Intestine

Developments in material science and manufacturing innovation are creating a purpose-built capsules for enteric drug delivery

36. Esomeprazole Pellet Production for MUPS Applications – High-Precision Fluid Bed Coating

Fluid bed processors are utilising air flow bed technology in the development of pellet coating

38. Making Inhaled Therapies Fit for the Future: Improving the Sustainability of Pressurised Metered Dose Inhalers

Formulation changes are helping to make pMDIs more sustainable

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41. How Flexible Containment Is Helping Manufacturers Meet Demand for Highly Potent Drugs

Why are manufacturers choosing flexible containment over traditional rigid isolators?

Lab Automation

43. Next-Level Digitalisation: Smart Pharma Production Gets Even Smarter

How can companies improve lab digitalisation to aid growth?

EXECUTIVE DIRECTOR 
PMGroup Worldwide Ltd
Karl Equi

GROUP MANAGING EDITOR
Iona Everson

DEPUTY EDITOR
George Barker

EDITORIAL AND PRODUCTION ASSISTANT 
Charlie Blackie-Kelly

EDITORIAL ASSISTANTS
James Spargo 
Betsy Goodfellow

SALES
Simon Caplan

DESIGN

Peter May

FRONT COVER
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Innovations in Pharmaceutical Technology (ISSN: 1471-7204, USPS No: 025082) is published four times a year – March, June, September, and December – by Samedan Ltd.

The opinions and views expressed by the authors in this book are not necessarily those of the Editor the Publisher and, while every care has been taken in the preparation of the book, the Editor and the Publisher are not responsible for such opinions and views or for
any inaccuracies in the articles.

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© 2023 Samedan Ltd
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