As the days become shorter again, and the weather cools down after a long summer, it’s the perfect time for reflecting on the year’s subjects of interest and musing about how these might be developed in the future.

Refeyn kicks off IPT Autumn 2025 with a discussion about single-particle technologies in pharma imaging (page 10), followed by ACBio highlighting super-resolution microscopy as a new technology for the sector (page 14). More revelations come from Delong Instruments about low voltage electron microscopy (page 18), and Miltenyi explores how using a great starting sample is key to next-generation sequencing (page 21).

Leading our Manufacturing section is Natoli, demonstrating tablet density uniformity (page 24). Mettler-Toledo gives us eight reasons why advanced contamination detection systems are essential to pharma manufacturing (page 26); clone selection’s importance in cell line development is explored by Bionova Scientific (page 29); and Ingenza explains what biocatalysis is and its key role in small molecule process development (page 34). A highlight of this section is CARBOGEN AMCIS’ spotlight on its ability to ‘support complex molecules and challenging formulations from early development to commercialisation’ (page 32).

Newcells begins our Discovery & Development section by speaking about predictive in vitro technologies in the sector (page 38), while Sapio Sciences deep-dives into transformations in proteomics and the resulting effect (page 41). Charles River Labs (page 45) and CPTx (page 48) close this topic with discussions on viral clearance studies and single-stranded DNA, respectively.

Artificial intelligence is the key term in this issue’s Digital section. Companies focus on its use in: de novo protein design (DenovAI, page 52); drug discovery and development (AION Labs, page 56); and software-as-a-service (Mareana, page 60).

Lastly, SPT Labtech finishes IPT Autumn with a focus on automation in the pharma lab, and how the industry is translating great ideas into actionable workflows (page 63).

Thank you for reading IPT Autumn, and we look forward to welcoming you back in December with our final issue of 2025!