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Manufacturing

Innovations in pharmaceutical Manufacturing Including Capsuling, Tabletting, Additive Manufacturing, Biomanufacturing Operations

Articles

Multi-particulate formulations: the power of many
Multi-particulate formulations: the power of many

After assessing the various routes of drug administration, oral delivery stands out as the safest and, as a result, the most universally accepted among patients. Single-unit dosage forms, including tablets followed by capsules, have been identified as the preferred designs for immediate or modified release formulations

20 December 2023Manufacturing
Inhaled medicines and particle size analysis
Inhaled medicines and particle size analysis

Drug administration by inhalation is an established technique for treating respiratory and systemic diseases. Effective drug delivery to the lungs requires the aerosolisation and dispersion of a formulation into particles or droplets in the inhalable size range, typically an aerodynamic diameter below 5 µm. In many cases, particle engineering is used to optimise a formulation for efficacy

20 December 2023Manufacturing
Addressing bottlenecks in AAV analysis for efficient manufacturing
Addressing bottlenecks in AAV analysis for efficient manufacturing

Refeyn discusses the challenges associated with AAV manufacture, the key analytical techniques currently used to facilitate insight into AAV samples and novel techniques striving to overcome current limitations

20 December 2023Manufacturing
Balancing the evolution of MES with traditional methodologies
Balancing the evolution of MES with traditional methodologies

By seamlessly integrating a dynamic MES into digitisation road maps, companies have achieved greater operational efficiency, data integrity and harnessed real-time insights to meet their strategic goals

20 December 2023Manufacturing
Natoli Engineering, an industry leader in tablet and encapsulation success
Natoli Engineering, an industry leader in tablet and encapsulation success

Natoli engineering has made significant contributions to the pharmaceutical and nutraceutical industries. Specialising in tablet compression and encapsulation technology, innovative machines, tooling and solutions that enhance tablet and encapsulation manufacturing processes, Natoli has advanced manufacturing technologies and practices worldwide

24 September 2023Manufacturing
The microneedle’s edge: growth and opportunity in emerging technology
The microneedle’s edge: growth and opportunity in emerging technology

While the drug-device combination product industry is always investing in technology that could better meet the needs of patients, governments and sponsors, the COVID-19 pandemic has accelerated the process, bringing in more outside investment and a broader range of organisations in active development

24 September 2023Manufacturing
mRNA therapeutics: development and manufacturing trends in a rapidly evolving space
mRNA therapeutics: development and manufacturing trends in a rapidly evolving space

What are some trends in the mRNA space surrounding the growing desire for speed-to-market, and what hurdles are impeding the achievement of this goal?

24 September 2023Manufacturing
Integrated development strategies for drug product optimisation
Integrated development strategies for drug product optimisation

Drug product optimisation, also known as reformulation, is a development step required by all drugs en route to market. This process takes a long time, carries a considerable cost and places significant emphasis on the predictive power of laboratory and preclinical assessments. What are some alternative pathways available to development teams?

24 September 2023Manufacturing
Excipient-Binder Scale for Direct Compression and Dry Granulation Tabletting
Excipient-Binder Scale for Direct Compression and Dry Granulation Tabletting

For different binder-diluent ratios on the tablet mechanical strength, a proposed scale could serve as a ‘guiding torch’ for various formulators while designing preclinical or early phase formulations

7 June 2023Manufacturing
Leveraging CLD Technology to Overcome Associated Challenges
Leveraging CLD Technology to Overcome Associated Challenges

High-titre CLD platform is an effective tool to overcome a number of challenges when developing a cell line. What are the challenges associated with developing a high-titre CLD platform and how can utilising novel technologies help overcome them?

7 June 2023Manufacturing
The Manufacturing of Nanodrug Carriers: from Concept to Practice
The Manufacturing of Nanodrug Carriers: from Concept to Practice

Nanodrug carriers have gained increased attention in the pharma industry since they were used in the fight against COVID-19. What are they, and how can regulations improve the manufacture of them?

7 June 2023Manufacturing
Critical Tablet Press Design Considerations for Continuous Manufacturing Applications
Critical Tablet Press Design Considerations for Continuous Manufacturing Applications

What are the differences and key design features which characterise successful tablet press performance in a continuous manufacturing setting?

7 June 2023Manufacturing