Manufacturing

Manufacturing

Innovations in pharmaceutical Manufacturing Including Capsuling, Tabletting, Additive Manufacturing, Biomanufacturing Operations

Natoli Engineering, an industry leader in tablet and encapsulation successNatoli Engineering, an industry leader in tablet and encapsulation success
Natoli Engineering, an industry leader in tablet and encapsulation success

Natoli engineering has made significant contributions to the pharmaceutical and nutraceutical industries. Specialising in tablet compression and encapsulation technology, innovative machines, tooling and solutions that enhance tablet and encapsulation manufacturing processes, Natoli has advanced manufacturing technologies and practices worldwide

Sep 24, 2023 Manufacturing
The microneedle’s edge: growth and opportunity in emerging technologyThe microneedle’s edge: growth and opportunity in emerging technology
The microneedle’s edge: growth and opportunity in emerging technology

While the drug-device combination product industry is always investing in technology that could better meet the needs of patients, governments and sponsors, the COVID-19 pandemic has accelerated the process, bringing in more outside investment and a broader range of organisations in active development

Sep 24, 2023 Manufacturing
mRNA therapeutics: development and manufacturing trends in a rapidly evolving spacemRNA therapeutics: development and manufacturing trends in a rapidly evolving space
mRNA therapeutics: development and manufacturing trends in a rapidly evolving space

What are some trends in the mRNA space surrounding the growing desire for speed-to-market, and what hurdles are impeding the achievement of this goal?

Sep 24, 2023 Manufacturing
Integrated development strategies for drug product optimisationIntegrated development strategies for drug product optimisation
Integrated development strategies for drug product optimisation

Drug product optimisation, also known as reformulation, is a development step required by all drugs en route to market. This process takes a long time, carries a considerable cost and places significant emphasis on the predictive power of laboratory and preclinical assessments. What are some alternative pathways available to development teams?

Sep 24, 2023 Manufacturing
Excipient-Binder Scale for Direct Compression and Dry Granulation TablettingExcipient-Binder Scale for Direct Compression and Dry Granulation Tabletting
Excipient-Binder Scale for Direct Compression and Dry Granulation Tabletting

For different binder-diluent ratios on the tablet mechanical strength, a proposed scale could serve as a ‘guiding torch’ for various formulators while designing preclinical or early phase formulations

Jun 7, 2023 Manufacturing
Leveraging CLD Technology to Overcome Associated ChallengesLeveraging CLD Technology to Overcome Associated Challenges
Leveraging CLD Technology to Overcome Associated Challenges

High-titre CLD platform is an effective tool to overcome a number of challenges when developing a cell line. What are the challenges associated with developing a high-titre CLD platform and how can utilising novel technologies help overcome them?

Jun 7, 2023 Manufacturing
The Manufacturing of Nanodrug Carriers: from Concept to PracticeThe Manufacturing of Nanodrug Carriers: from Concept to Practice
The Manufacturing of Nanodrug Carriers: from Concept to Practice

Nanodrug carriers have gained increased attention in the pharma industry since they were used in the fight against COVID-19. What are they, and how can regulations improve the manufacture of them?

Jun 7, 2023 Manufacturing
Critical Tablet Press Design Considerations for Continuous Manufacturing ApplicationsCritical Tablet Press Design Considerations for Continuous Manufacturing Applications
Critical Tablet Press Design Considerations for Continuous Manufacturing Applications

What are the differences and key design features which characterise successful tablet press performance in a continuous manufacturing setting?

Jun 7, 2023 Manufacturing
Improving Machinery in Pharmaceutical ManufacturingImproving Machinery in Pharmaceutical Manufacturing
Improving Machinery in Pharmaceutical Manufacturing

IPT talks to Richard Stedman of ACG Engineering about the rise of connected and digitalised machines, and how these will improve pharmaceutical manufacturing in the future

Jun 7, 2023 Manufacturing
Enteric Capsule Innovation: How Capsule Technology is Helping API Reach into the Small IntestineEnteric Capsule Innovation: How Capsule Technology is Helping API Reach into the Small Intestine
Enteric Capsule Innovation: How Capsule Technology is Helping API Reach into the Small Intestine

How are current events in drug development demanding better enteric delivery solutions, and how is material science and manufacturing innovation creating a purpose-built capsule able to go the distance – all while reducing the cost and complexity of enteric development and delivery?

Apr 3, 2023 Manufacturing
Esomeprazole Pellet Production for MUPS Applications – High-Precision Fluid Bed CoatingEsomeprazole Pellet Production for MUPS Applications – High-Precision Fluid Bed Coating
Esomeprazole Pellet Production for MUPS Applications – High-Precision Fluid Bed Coating

MUPS formulations are a widely used pharmaceutical dosage form for esomeprazole, a proton pump inhibitor. For this purpose, micropellets are coated with the active ingredient and administered in the form of tablets or capsules. An appropriate solution for the coating of micropellets is the use of fluid bed processors which utilise air flow bed technology

Apr 3, 2023 Manufacturing
Making Inhalants Fit the Future: Improving the Sustainability of Pressurised Metered Dose InhalersMaking Inhalants Fit the Future: Improving the Sustainability of Pressurised Metered Dose Inhalers
Making Inhalants Fit the Future: Improving the Sustainability of Pressurised Metered Dose Inhalers

Since their introduction in 1956, pressurised metered dose inhalers (pMDIs) have become the dominant treatment choice for patients suffering from common respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). However, unbeknown to most patients and many doctors, pMDIs account for 3.9% of NHS’s annual carbon emissions.1 Here we will discuss how formulation changes might be the answer to the pMDI-related sustainability problem

Apr 3, 2023 Manufacturing