Category Cover

Discovery and Development

Innovations in pharmaceutical Discovery and Development Including Bioinformatics, Proteomics, Nanotechnology, Formulation and Recipients, Extractables and Leachables

article-item
ssDNA: a novel approach to overcome efficacy and immunogenicity challenges in genetic medicines

What is single-stranded DNA and why is it a viable viral vector alternative?

30 September 2025Discovery and Development
article-item
The increasing pivotal role of predictive in vitro technologies in drug discovery

How will innovative human-centred in vitro testing strategies contribute to accelerating the delivery of safer and more effective therapies to patients without, or with minimal, use of animal models?

30 September 2025Discovery and Development
article-item
Viral clearance in advanced therapies

Should viral clearance studies be required for genetically engineered viral vectors and viral vector-derived products?

30 September 2025Discovery and Development
article-item
How proteomics and digital transformation can redefine therapeutic discovery

How are recent advances in proteomics, such as artificial intelligence and machine learning, transforming drug discovery and development?

30 September 2025Discovery and Development
article-item
Leveraging ligand-based and structure-based approaches for advancing drug discovery

Computational drug discovery relies on two major approaches: ligand-based drug design and structure-based drug design. This article discusses the principles, techniques and applications of both methodologies, as well as a combined approach; providing insights into when to use each method and highlighting complementary insights provided by the two approaches

17 June 2025Discovery and Development
article-item
The use of genetic information in precision medicine

The pharma industry needs a way to ensure the right therapies are getting to the right patients, in a timely and cost-effective way. How are advances in researchers’ understanding of genomics aiding not only precision medicine for rare diseases, but also for common health conditions?

17 March 2025Discovery and Development
article-item
Overcoming delivery barriers to unlock the full potential of RNA-based medicine

While RNA molecules have demonstrated promising results as therapeutics for difficult-to-treat disease indications, their current limitations in terms of delivery mean their full potential is not being realised. How can this be overcome?

17 March 2025Discovery and Development
article-item
The evolution and future of DNA sequencing

The evolution of DNA sequencing – from Sanger to cutting-edge next generation approaches like Illumina, Nanopore and Single Molecule, Real-Time (PacBio) sequencing – has brought advances in speed, cost and accessibility. However, what challenges are faced in throughput scale-up, and what promise does automation hold for transforming genomics and personalised medicine?

17 March 2025Discovery and Development
article-item
Exploring new dimensions with spatial multi-omics

The implementation of spatial technologies advances disease research, but challenges must be overcome before spatial multi-omics becomes broadly accessible

17 March 2025Discovery and Development
article-item
Harnessing spatial biology in drug discovery and development:navigating opportunities and challenges

How is current spatial biology being utilised in drug discovery and development for complex disease treatments, and how can it be improved?

6 December 2024Discovery and Development
article-item
Advancing cell line development: how next-gen innovation meets industry needs

Cell line development is integral to research and biotherapeutic production, and so ensuring this process is as robust as possible through next-generation technology is in the industry’s best interests

6 December 2024Discovery and Development
article-item
From ACGT to AI: visionary advances in oligonucleotide synthesis

Considering the importance and cost associated with oligonucleotide-based therapeutics, how can innovative computing imaging techniques be used to aid in the process, while also creating an audit trail and increasing the data derived from these experiments?

22 September 2024Discovery and Development