About the Bruker MALDI Biotyper (MBT) platform
The MBT enables molecular identification of bacteria, yeasts and fungi. Classification and identification of microorganisms is achieved reliably and quickly using a molecular approach based on proteomic fingerprinting by high-throughput MALDI-TOF MS. Applications include clinical routine microbial identification, environmental and pharmaceutical analysis, taxonomical research, food and consumer product safety and quality control, as well as marine microbiology. In many international laboratories, the MBT has replaced classical biochemical testing for bacterial identification due to its accuracy, speed, extensive species coverage, ease of use, minimal sample preparation and cost-effectiveness. MBT products are available in a research use only (RUO) version, as general purpose (GP) version, as the FDA-cleared MBT CA System, or in an IVD-CE version. The MBT also has IVD medical device registrations in numerous other countries.
About the Bruker LiquidArray technologyThe innovative LiquidArray technology optimises asymmetrical multiplex PCR for creating excess single-stranded amplicons with detection by Lights-On/-Off probes that contain a quencher (Lights-Off) or both fluorophore and quencher (Lights-On). If both probes are hybridised in proximity on the amplicon, the quencher of the Lights-Off probe eliminates the fluorescence emitted by the Lights-On probe. During melting curve analysis, Lights-On/-Off probes detach from the amplicon at specific temperatures. In the unbound state, Lights-On probes cannot emit, and as fluorescence is either emitted or suppressed, specific fluorescence signatures are generated by the unique FluoroCycler XT thermocycler for the LiquidArray multiplex PCR technology. The LiquidArray technology supports multiplexed assays where a large number of targets is analysed simultaneously from single samples. For example, the LiquidArray-powered, WHO-endorsed FluoroType MTDBR VER 2.0 assay detects more than 500 genotypes by the combined analysis of up to 45 different mutations in mycobacteria.
About Bruker CorporationBruker is enabling scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular and cell biology research, in applied and pharma applications, in microscopy and nanoanalysis, as well as in industrial applications. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. For more information, please visit:
www.bruker.com.